Because of the substantial risk of seizure associated with clozaril use, patients should be advised not to engage in any activity where sudden loss of consciousness could cause serious risk to themselves or others, e.
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hyperglycemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotics including clozaril.
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fewer than 1 of patients taking clozaril may develop agranulocytosis, a potentially life-threatening adverse event.
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