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The interaction of apcalis-sx with alcohol was evaluated in 3 clinical pharmacology studies.

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Use of protonix in pediatric patients 1 year through 16 years of age for short-term treatment up to eight weeks of ee associated with gerd is supported by a extrapolation of results from adequate and well-controlled studies that supported the approval of protonix for treatment of ee associated with gerd in adults, and b safety, effectiveness, and pharmacokinetic studies performed in pediatric patients see clinical studies and clinical pharmacology .

If these potentially hazardous signs occur, treatment should be stopped, plasma lithium concentrations redetermined, and steps taken to reverse lithium toxicity.