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in subjects with severe renal impairment 24-hr crcl 30 ml min, cockcroft-gault and end-stage renal disease, elimination half-lives were significantly prolonged, increasing exposures to pristiq; therefore, dosage adjustment is recommended in these patients see dosage and administration 2.
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sometimes patients have unusual personal circumstances that do not fit normal eligibility guidelines, which means that the applicant must file a formal appeal to get into the pristiq pap program.
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more patients experienced these events during pristiq treatment as compared to placebo.
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