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Enterohepatic recycling is suggested by secondary peaking of plasma doxazosin mesylate concentrations.

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pubmed 14985103 takara k, sakaeda t, kakumoto m, tanigawara y, kobayashi h, okumura k, ohnishi n, yokoyama t effects of alpha-adrenoceptor antagonist doxazosin on mdr1-mediated multidrug resistance and transcellular transport.

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like prazosin, doxazosin produced virtually no change in heart rate.

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reductions of 18 in mean maximum plasma concentration and 12 in the area under the concentration-time curve occurred when doxazosin mesylate was administered with food.

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